Nr 2 2024 – Histamin
Bly – en orsak till neurologiska funktionsnedsättningar
[1] Socialstyrelsen, Fortsatt kraftig ökning av adhd-diagnoser, 2023-11-28. Hämtad 2024-05-03. Fortsatt kraftig ökning av adhd-diagnoser – Socialstyrelsen
2 Gundacker C, Forsthuber M, Szigeti T, Kakucs R, Mustieles V, Fernandez MF, Bengtsen E, Vogel U, Hougaard KS, Saber AT. Lead (Pb) and neurodevelopment: A review on exposure and biomarkers of effect (BDNF, HDL) and susceptibility. Int J Hyg Environ Health. 2021 Sep;238:113855.
3 Grandjean P, Landrigan PJ. Neurobehavioural effects of developmental toxicity. Lancet Neurol. 2014 Mar;13(3):330-8.
4 Livsmedelsverket, Bly. Hämtad 2024-05-03. Bly (livsmedelsverket.se)
5 ATSDR. ATSDR Substance Priority List; ATSDR: Atlanta, GA, USA, 2017.
6 Efsa 2012. Lead dietary exposure in the European population. Scientific Report of Efsa. The Efsa Journal 10(7):2831.
7 American Academy of Pediatrics Committee on Environmental Health. Lead exposure in children: Prevention, detection, and management; CCHMC guideline. Pediatrics 2005, 116, 1036.
8 Efsa 2012. Lead dietary exposure in the European population. Scientific Report of Efsa. The Efsa Journal 10(7):2831.
9 Strömberg U, Lundh T, Skerfving S. Yearly measurements of blood lead in Swedish children since 1978: the declining trend continues in the petrol-lead-free period 1995-2007. Environ Res. 2008 Jul;107(3):332-5.
10 Livsmedelsverket. 2020. Contaminants in blood and urine from adolescents in Sweden. Results from the national dietary survey Riksmaten Adolescents 2016-17. Livsmedelsverkets samarbetsrapport S 2020 nr 01.
11 Gulson, B.L.; Mizon, K.J.; Korsch, M.J.; Palmer, J.M.; Donnelly, J.B. Mobilization of lead from human bone tissue during pregnancy and lactation—A summary of long-term research. Sci. Total Environ. 2003, 303, 79–104.
12 Ettinger AS, Hu H, Hernandez-Avila M. Dietary calcium supplementation to lower blood lead levels in pregnancy and lactation. J Nutr Biochem. 2007 Mar;18(3):172-8.
[1]3 EFSA Scientific opinion on lead in food EFSA J, 8 (4) (2010), p. 1570, 10.2903/j.efsa.2010.1570
[1]4 Boverket, Bly i tappvatten. Hämtad 2024-03-12. Bly i tappvatten – Boverket
15Smith MR, Yevoo P, Sadahiro M, Austin C, Amarasiriwardena C, Awawda M, Arora M, Dudley JT, Morishita H. Integrative bioinformatics identifies postnatal lead (Pb) exposure disrupts developmental cortical plasticity. Sci Rep. 2018 Nov 6;8(1):16388.
16 Zheng W, Aschner M, Ghersi-Egea JF. Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol Appl Pharmacol. 2003;192:1–11.
17 Lidsky TI, Schneider JS. Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain. 2003 Jan;126(Pt 1):5-19.
[1]8 Bellinger DC. Effect modification in epidemiological studies of low-level neurotoxicant exposures and health outcomes. [Review]. Neurotoxicol Teratol 2000; 22: 133±40.
19 Schneider JS, Lee MH, Anderson DW, Zuck L, Lidsky TI. Enriched environment during development is protective against lead-induced neurotoxicity. Brain Res 2001; 896: 48–55.
Vad är Histamin?
1Jarisch R.Histamin-Intoleranz, Histamin und Seekrankheit. 2004. Thiemeverlag.
2Bengtsson U. Histaminintolerans. Näringsmedicinsk tidskrift. 2014;6: 23-24.
3Nylander M. Histaminintolerans. Medicinsk Access. 2015; 4-5: 26-29.
4Hartter E et al. Placebo controlled observational study to proof the efficacy and the absence of side effects of an oral supplementation in histamine intolerance. Report from: Arbeitsmedizinisches Zentrum, 1060 Vienna, Austria. 2005,pp.5-21.
5Ionescu G et al. Cofactor levels of mono- and diamine oxidase in atopic eczema. Allergy. 1989;44:298-300.
6Sattler J et al. Food induced histaminosis as an epidemiological problem: plasmahistamine elevation and haemodynamic alterations after oral histamine administration and blockade of diamine oxidase (DAO). Agents Actions. 1988;23:361-365.
7Zimatkin SM & Antichtchik OV. Alcohol-histamine interactions.Alcohol. 1999;34:141-147.
8James SM et al. A new redox cofactor in eukaryotic enzymes: 6-hydroxydopa at the active site of bovine serum amine oxidase. Science. 1990;248:981-987.
9Komericki P et al. Histamine intolerance: lack of reproducibility of single symptoms by oral provocation with histamine: A randomised, double-blind, placebo-controlled cross-over study. Wien KlinWochenschr. The Middle European Journal of Medicine.2010. pp 1-6 , DOI 10.1007/s00508-010-1506-y, Springer Verlag, Austria.
10Nylander M. Riktigt Näringsintag & God Munhygien är grundläggande för bästa hälsa. Prod. T&M Media, s. 3–58.
DAO-hämmare
1 Comas-Basté O., Sánchez-Pérez S., Veciana-Nogués M.T., et.al. Histamine Intolerance: The Current State of the Art. Biomolecules. 2020:14;10(8) DOI: 10.3390/biom10081181
2Hrubisko M., Danis R., Huorka M., Wawruch M. Histamine Intolerance—The More We Know the Less We Know. A Review. Nutrients. 2021:13;7 DOI: 10.3390/nu13072228
3 Tobajas Y., Alemany-Fornés M., Samarra I., et.al. Interaction of Diamine Oxidase with Psychostimulant Drugs for ADHD Management. Journal of Clinical Medicine. 2023. DOI: 10.3390/jcm12144666
4International Society of DAO Deficiency. DAO blocking foods – deficitdao.org – Official Scientific Society
5 Zimatkin S.M., Anichtchik O.V. Alcohol-histamine interactions. Alcohol & Alcoholism. 1999:34;2 DOI: 10.1093/alcalc/34.2.141
6Gill D, Barradas M, Fonseca V, Dandona P. Plasma histamine concentrations are elevated in patients with diabetes mellitus and peripheral vascular disease. Metabolism. 1989;38(3):243-247. DOI: 10.1016/0026-0495(89)90082-6
7 Wang K-Y., Tanimoto A., Yamada S., et.al. Histamine Regulation in Glucose and Lipid Metabolism via Histamine Receptors. The American Journal of Pathology. 2010:177;2 DOI: https://doi.org/10.2353/ajpath.2010.091198
8Fogel WA, Chmielecki C, Grałek M, Maslinski C. Histamine metabolism in diabetic rats. Agents and Actions. 1990:243-246. DOI:10.1007/bf01969050
Fibromyalgi – histamin en del av problematiken?
[1] Vårdgivare Skåne, Fibromyalgi. Hämtad 2024-06-07. Fibromyalgi – AKO Skåne-riktlinje för primärvården – Vårdgivare Skåne (skane.se)
2 Okutan G, Ruiz Casares E, Perucho Alcalde T, Sánchez Niño GM, Penadés BF, Terrén Lora A, Torrente Estríngana L, López Oliva S, San Mauro Martín I. Prevalence of Genetic Diamine Oxidase (DAO) Deficiency in Female Patients with Fibromyalgia in Spain. Biomedicines. 2023 Feb 22;11(3):660
3 Conti, P.; Gallenga, C.E.; Caraffa, A.; Ronconi, G.; Kritas, S.K. Impact of mast cells in fibromyalgia and low-grade chronic inflammation: Can IL-37 play a role? Dermatol. Ther. 2020, 33, e13191. [CrossRef]
4 Gomez-Arguelles JM, Caceres O, Blanco M, Maestu C, Martin F. Improvement of digestive symptoms in fibromyalgia patients following a diet modification according to histamine release test – an observational study. Reumatologia. 2022;60(3):209-212.
5 Comas-Basté, O.; Sánchez-Pérez, S.; Veciana-Nogués, M.T.; Latorre-Moratalla, M.; Vidal-Carou, M.D.C. Histamine Intolerance: The Current State of the Art. Biomolecules 2020, 10, 1181. [CrossRef] [PubMed]
6 Okutan G, Perucho Alcalde T, Ruiz Casares E, Penadés BF, Sánchez Niño GM, Terrén Lora A, López Oliva S, Torrente Estríngana L, Duelo A, San Mauro Martín I. Cumulative effect of AOC1 gene variants on symptoms and pathological conditions in adult women with fibromyalgia: a pilot study. Front Genet. 2023 Jun 9;14:1180777.
Adhd och istamin – finns det en koppling?
ADHD
[1] Carthy E, Ellender T. Histamine, Neuroinflammation and Neurodevelopment: A Review. Front Neurosci. 2021 Jul 14;15:680214.
2 Lin, J. S., Anaclet, C., Sergeeva, O. A., and Haas, H. L. (2011). The waking brain: an update. Cell Mol. Life Sci. 68, 2499–2512.
3Takahashi, K., Lin, J. S., and Sakai, K. (2006). Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse. J. Neurosci. 26, 10292–10298.
4 Torrealba, F., Riveros, M. E., Contreras, M., and Valdes, J. L. (2012). Histamine and motivation. Front. Syst. Neurosci. 6:51.
5 Polanczyk, G.V., Willcutt, E.G., Salum, G.A., Kieling, C., Rohde, L.A. ADHD prevalence estimates across three decades: An updated systematic review and meta-regression analysis. Int. J. Epidemiol. 2014, 43, 434–442.
6 Pelsser LM, et. al. Effects of a restricted elimination diet on the behaviour of children with attention-deficit hyperactivity disorder (INCA study): a randomised controlled trial. Lancet. 2011 Feb 5;377(9764):494-503.
7 Egger J et al. Controlled trial of oligoantigenic treatment in the hyperkinetic syndrome. Lancet 1985 Mar 9;1(8428):540-5
8 Anand D, Colpo GD, Zeni G, Zeni CP, Teixeira AL. Attention-Deficit/Hyperactivity Disorder and Inflammation: What Does Current Knowledge Tell Us? A Systematic Review. Front Psychiatry. 2017 Nov 9;8:228.
9Schmitt J, Buske-Kirschbaum A, Tesch F, Trikojat K, Stephan V, Abraham S, Bauer A, Nemat K, Plessow F, Roessner V. Increased attention-deficit/hyperactivity symptoms in atopic dermatitis are associated with history of antihistamine use. Allergy. 2018 Mar;73(3):615-626.
10 Blasco-Fontecilla H, Bella-Fernández M, Wang P, Martin-Moratinos M, Li C. Prevalence and Clinical Picture of Diamine Oxidase Gene Variants in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Pilot Study. J Clin Med. 2024 Mar 14;13(6):1659.
1[1] Izquierdo-Casas, J., Comas-Basté, O.; Latorre-Moratalla, M.L., Lorente-Gascón, M., Duelo, A., Vidal-Carou, M.C., Soler-Singla, L. Low serum diamine oxidase (DAO) activity levels in patients with migraine. J. Physiol. Biochem. 2018, 74, 93–99.
Naturligt barkextrakt kan hjälpa mot pollenallergi
Phytother Res. 2010 Aug;24(8):1115-9.
Phytother Res. 2022 Jun;36(6):2352-2374.
3Pycnogenol® improvements in asthma management
Panminerva Medica, 01 Sep 2011, 53(3 Suppl 1):57-64
4Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women
Skin Pharmacol Physiol 2012;25(2):86-92.
Samma mat olika blodsocker
[1] Maja Wahlström, Susanna Palmer. Diabetes typ 2 i primärvård – utredning och uppföljning Dec 2022. Hämtad 2024-04-29. Diabetes typ 2 i primärvård – utredning och uppföljning (internetmedicin.se)
[1] National Diabetes Statistics Report, Estimates of Diabetes and Its Burden in the United States. Hämtad 2024-04-29. National Diabetes Statistics Report | Diabetes | CDC
[1] Guizar-Heredia R, Noriega LG, Rivera AL, Resendis-Antonio O, Guevara-Cruz M, Torres N, Tovar AR. A New Approach to Personalized Nutrition: Postprandial Glycemic Response and its Relationship to Gut Microbiota. Arch Med Res. 2023 Apr;54(3):176-188.
[1] Zeevi D et al. Personalized Nutrition by Prediction of Glycemic Responses. Cell. 2015 Nov 19;163(5):1079-1094.
[1] Vrolix R, Mensink RP. Variability of the glycemic response to single food products in healthy subjects. Contemp Clin Trials. 2010 Jan;31(1):5-11.
[1] Mendes-Soares H, Raveh-Sadka T, Azulay S, Edens K, Ben-Shlomo Y, Cohen Y, Ofek T, Bachrach D, Stevens J, Colibaseanu D, Segal L, Kashyap P, Nelson H. Assessment of a Personalized Approach to Predicting Postprandial Glycemic Responses to Food Among Individuals Without Diabetes. JAMA Netw Open. 2019 Feb 1;2(2):e188102.
[1] Shishehbor F, Mansoori A, Shirani F. Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials. Diabetes Res Clin Pract. 2017 May;127:1-9.
[1] Nitta A, Imai S, Kajiayama S, Matsuda M, Miyawaki T, Matsumoto S, Kajiyama S, Hashimoto Y, Ozasa N, Fukui M. Impact of Dietitian-Led Nutrition Therapy of Food Order on 5-Year Glycemic Control in Outpatients with Type 2 Diabetes at Primary Care Clinic: Retrospective Cohort Study. Nutrients. 2022 Jul 13;14(14):2865.
[1] Meng H, Matthan NR, Ausman LM, Lichtenstein AH. Effect of prior meal macronutrient composition on postprandial glycemic responses and glycemic index and glycemic load value determinations. Am J Clin Nutr. 2017 Nov;106(5):1246-1256.
[1] Sung J, Kim S, Cabatbat JJT, et al. Global metabolic interaction network of the human gut microbiota for context-specific community-scale analysis. Nat Commun. 2017;8:15393.
[1] Khan MT, Nieuwdorp M, Bäckhed F. Microbial modulation of insulin sensitivity. Cell Metab. 2014;20(5):753-760.
[1] Shuiming Xiao, Na Fei, Xiaoyan Pang, Jian Shen, Linghua Wang, Baorang Zhang, Menghui Zhang, Xiaojun Zhang, Chenhong Zhang, Min Li, Lifeng Sun, Zhengsheng Xue, Jingjing Wang, Jie Feng, Feiyan Yan, Naisi Zhao, Jiaqi Liu, Wenmin Long, Liping Zhao, A gut microbiota-targeted dietary intervention for amelioration of chronic inflammation underlying metabolic syndrome, FEMS Microbiology Ecology, Volume 87, Issue 2, February 2014, Pages 357–367.
[1] Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H, Bushman FD, Lewis JD. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011 Oct 7;334(6052):105-8.
[1] Duncan SH, Belenguer A, Holtrop G, Johnstone AM, Flint HJ, Lobley GE. Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol. 2007 Feb;73(4):1073-8.
Oxymel – En antik vinägrett med superkraft
1Darani NS, Vaghasloo MA, Kazemi A, Amri H, Rampp T, Hashempur MH. Oxymel: A systematic review of preclinical and clinical studies. Heliyon. 2023 Nov 21;9(12):e22649. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10730569/
2Nejatbakhsh F, Karegar-Borzi H, Amin G, Eslaminejad A, Hosseini M, Bozorgi M, Gharabaghi MA. Squill Oxymel, a traditional formulation from Drimia Maritima (L.) Stearn, as an add-on treatment in patients with moderate to severe persistent asthma: A pilot, triple-blind, randomized clinical trial. J Ethnopharmacol. 2017 Jan 20;196:186-192.
3Chen Q, Zhou K. Acetic Acid Use in Chronic Wound Healing: A Multiple Case Series. J Wound Ostomy Continence Nurs. 2022 May-Jun 01;49(3):286-289.
4Harrison F, Blower A, de Wolf C, Connelly E. Sweet and sour synergy: exploring the antibacterial and antibiofilm activity of acetic acid and vinegar combined with medical-grade honeys. Microbiology (Reading). 2023 Jul;169(7):001351.
5Smaropoulos E, Cremers NAJ. Treating severe wounds in pediatrics with medical grade honey: A case series. Clin Case Rep. 2020 Jan 31;8(3):469-476.
5Deluca L. Ancient Honey-and-Vinegar Combo Could Actually Treat Infected Wounds. Scientific American 2023-10-01. https://www.scientificamerican.com/article/ancient-honey-and-vinegar-combo-could-actually-treat-infected-wounds/
7Darani NS, Vaghasloo MA, Kazemi A, Amri H, Rampp T, Hashempur MH. Oxymel: A systematic review of preclinical and clinical studies. Heliyon. 2023 Nov 21;9(12):e22649.
8Guan BM. Oxymel: A Not-So-New Natural Treatment for Infection. Institute for Natural Medicine 2024-01-18. https://naturemed.org/oxymel-a-not-so-new-natural-treatment-for-infection/
Kan ubiquinol Q10 förbättra kvaliteten på spermierna?
[1] Internetmedicin. Infertilitet, manlig. Hämtad 2023-11-08. https://www.internetmedicin.se/behandlingsoversikter/endokrinologi/infertilitet-manlig
[1] Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations – PubMed (nih.gov)
[1] Hosoe K. et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers – PubMed (nih.gov)
[1] Ikematsu H et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol. 2006 Apr;44(3):212-8. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial – PubMed (nih.gov)
[1] García-Corzo L et al. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency. Biochim Biophys Acta. 2014 Jul;1842(7):893-901. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency – PubMed (nih.gov)
[1] Zhang Y et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men – PubMed (nih.gov)
[1] 1177. Så fungerar det manliga könsorganet. Hämtad 2023-11-08.
[1] Hirata S et al. Spermatozoon and mitochondrial DNA. Reprod Med Biol. 2002 Dec 11;1(2):41-47. Spermatozoon and mitochondrial DNA – PMC (nih.gov)
[1] Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Curr Opin Obstet Gynecol. 2015 Jun;27(3):175-81. Oocyte mitochondrial function and reproduction – PMC (nih.gov)
[1] Vishvkarma R et al. Coenzyme Q10 effect on semen parameters: Profound or meagre? Andrologia. 2020;52:e13570. Coenzyme Q10 effect on semen parameters: Profound or meagre? – PubMed (nih.gov)
[1] Kao SH et al. Increase of oxidative stress in human sperm with lower motility. Fertil Steril. 2008 May;89(5):1183-1190. Increase of oxidative stress in human sperm with lower motility – Fertility and Sterility (fertstert.org)
[1] Nowicka-Bauer K, Nixon B. Molecular Changes Induced by Oxidative Stress that Impair Human Sperm Motility. Antioxidants (Basel). 2020 Feb 4;9(2):134. Molecular Changes Induced by Oxidative Stress that Impair Human Sperm Motility – PubMed (nih.gov)
[1] Alahmar AT et al. Coenzyme Q10, oxidative stress, and male infertility: A review. Clin Exp Reprod Med. 2021 Jun;48(2):97-104. Coenzyme Q10, oxidative stress, and male infertility: A review – PubMed (nih.gov)
[1] Alahmar AT et al. Coenzyme Q10, oxidative stress markers, and sperm DNA damage in men with idiopathic oligoasthenoteratospermia. Clin Exp Reprod Med. 2021 Jun;48(2):150-155. Coenzyme Q10, oxidative stress markers, and sperm DNA damage in men with idiopathic oligoasthenoteratospermia – PubMed (nih.gov)
[1] Alahmar AT, Naemi R. Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre- and post-coenzyme Q10 therapy. Andrologia. 2022 Jun;54(5):e14385. Predictors of pregnancy and time to pregnancy in infertile men with idiopathic oligoasthenospermia pre‐ and post‐coenzyme Q10 therapy – PMC (nih.gov)
