Nr 2, 2020: Mitokondrier

Mitokondrierna – kroppens energiverk av Lina Åhlén, hälsoskribent

Marcheggiani F., Cirilli I., Orando P. et.al. Modulation of Coenzyme Q10 content and oxidative status in human dermal fibroblasts using HMG-CoA reductase inhibitor over a broad range of concentrations. From mitohormesis to mitochondrial dysfunction and accelerated aging. Aging. May 2019:10:11(9). https://www.ncbi.nlm.nih.gov/pubmed/31076563
Hsu C-C, Tseng L-M., Lee H-C. Role of mitochondrial dysfunction in cancer progression. 2016. March
Chen L., Knowlton A.A. Mitochondria and heart failure: new insights into an energetic problem. Minerva Cardiology. 2010. Apr 58(2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786553/
Mortiboys H., Macdonald R., Payne T. Translational approaches to restoring mitochondrial function in Parkinson’s disease. 2018. Jan (582). https://febs.onlinelibrary.wiley.com/doi/pdf/10.1002/1873-3468.12920
Pei-I T., Chin-Hsien L., Chung-Han H., et.al. PINK1 Phosphorylates MIC60/Mitofilin to Control Structural Plasticity of Mitochondrial Crista Junctions. Molecular Cell. 2018 March 69(5). https://parkinsonsnewstoday.com/2018/02/27/defects-in-mitochondria-linked-to-parkinsons-stanford-study/
Perez Ortiz J.M., Swerdlow R.H. Mitochondrial dysfuncion in Alzheimer’s disease: Role in pathogenesis and novel therapeutic opportunities. British Journal of Pharmacology. 2019:176. https://bpspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/bph.14585
Ames B., Liu J., Killilea D.W. Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-l- carnitine and/or R-α-lipoic acid. 2002. Feb 99(4). https://www.pnas.org/content/99/4/1876.short

Mitokondriefunktion – grundläggande för vår hälsa av Markus Mattiasson, biomedicinare och hälsoskribent

Metabolomik ger inblick i mitokondriens värld av Annie Pettersson, fil.mag. (biologi) från Uppsala universitet och fil.dr. (medicin) från Karolinska Institutet

Astarita G, Langridge J. J Nutrigenet Nutrigenomics. 2013;6(4-5):181-200. An emerging role for metabolomics in nutrition science.
Chen Q et al. Front Cell Neurosci. 2019 Apr 30;13:150. Urine Organic Acids as Potential Biomarkers for Autism-Spectrum Disorder in Chinese Children.
Depeint F et al. Chem Biol Interact. 2006 Oct 27;163(1-2):94-112. Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism.
Filler K et al. BBA Clin. 2014 Jun 1;1:12-23. Association of Mitochondrial Dysfunction and Fatigue: A Review of the Literature.
Gallagher R et al. Genetics in Medicine volume 20, pages 683–691(2018) Laboratory analysis of organic acids, 2018 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG)
Guillemin GJ et al. FEBS J. 2012 Apr;279(8):1356-65. Quinolinic acid, the inescapable neurotoxin.
Kałużna-Czaplińska et al. Nutrition Research. Volume 31, Issue 7, July 2011, Pages 497-502. B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children
Longo et al. Biochim Biophys Acta. 2016 Oct; 1863(10): 2422–2435. CARNITINE TRANSPORT AND FATTY ACID OXIDATION
McKillop et al. Diabetes Care. 2011 Dec; 34(12): 2624–2630.
Emerging Applications of Metabolomic and Genomic Profiling in Diabetic Clinical Medicine
Moskowitz A et al. J Intensive Care Med. 2016 Mar;31(3):187-92. The Association Between Admission Magnesium Concentrations and Lactic Acidosis in Critical Illness.
Nordholme et al. Läkartidningen. 2016;113:DR7E Tiaminbrist orsakade laktacidos hos patient med malnutrition – Många patienter i behov av behandling med tiamin missas sannolikt.
Noto A et al. J Matern Fetal Neonatal Med. 2014 Oct;27 Suppl 2:46-52. The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings.
Orozco JS et al. Transl Psychiatry. 2019 Oct 3;9(1):243. Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome.
Osiezagha, K et al. Innov Clin Neurosci. 2013 Apr; 10(4): 26–32. Thiamine Deficiency and Delirium
Pieczenik SR & Neustadt J. Exp Mol Pathol. 2007 Aug;83(1):84-92. Mitochondrial dysfunction and molecular pathways of disease.
Sun J et al. Per Med. 2013 Mar;10(2):149-161. Metabolomics as a tool for personalizing medicine: 2012 update.
Teagarden et al. Case Rep Crit Care. 2017;2017:5121032. Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient.
Tsoukalas D et al. Int J Mol Med. 2017 Jul;40(1):112-120. Application of metabolomics: Focus on the quantification of organic acids in healthy adults.

Deanna Minich – Vi måste ge mitokondrierna den näring de behöver av Nina Törmark, journalist

Fasta – ett kraftfullt verktyg för optimal hälsa av Annie Pettersson, fil.mag. (biologi) från Uppsala universitet och fil.dr. (medicin) från Karolinska Institutet

Dror, et al. Postprandial macrophage-derived IL-1β stimulates insulin and both synergistically promote glucose disposal and inflammation. Nature Immunology, January 2017
Seillet et al. Nat Immunol. 2020 Feb;21(2):168-177. The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity.
Anton et al. Obesity (Silver Spring). 2018 Feb;26(2):254-268. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.
de Cabo & Mattson. N Engl J Med 2019;381:2541-51. Effects of Intermittent Fasting on Health, Aging, and Disease
Harvie & Howell. Potential benefits and harms of intermittent energy restriction and intermittent fasting amongst obese, overweight and normal weight subjects — a narrative review of human and animal evidence. Behav Sci (Basel) 2017; 7(1): E4.
Furmli et al. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. BMJ Case Rep 2018; 2018:bcr-2017-221854.
Sutton et al. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab 2018; 27(6): 1212-1221.e3.
Nencioni et al. Fasting and cancer: molecular mechanisms and clinical application. Nat Rev Cancer 2018; 18: 707-19.
Choi et al. A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Rep 2016; 15: 2136-46.
Fitzgerald et al. Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis. Mult Scler Relat Disord 2018; 23: 33-9.
Johnson et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med 2007; 42: 665-74.
Cignarella et al. Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota. Cell Metab 2018; 27(6): 1222.e6-1235.e6.

Sött som socker men ändå inte av Pia Andrea, hälsoskribent

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