Nr 4 2023/1 2024 – Längre liv: Anti-aging & Longevity

1. Connelly E, Lee C, Furner-Pardoe J, Del Genio CI, Harrison F. A case study of the Ancientbiotics collaboration. Patterns (N Y). 2022 Dec 9;3(12):100632.

2. https://www.nottingham.ac.uk/news/pressreleases/2015/march/ancientbiotics—a-medieval-remedy-for-modern-day-superbugs.aspx

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4. Dalton T, Dowd SE, Wolcott RD, Sun Y, Watters C, Griswold JA, Rumbaugh KP. An in vivo polymicrobial biofilm wound infection model to study interspecies interactions. PLoS One. 2011;6(11):e27317.

5. Furner-Pardoe J, Anonye BO, Cain R, Moat J, Ortori CA, Lee C, Barrett DA, Corre C, Harrison F. Anti-biofilm efficacy of a medieval treatment for bacterial infection requires the combination of multiple ingredients. Sci Rep. 2020 Jul 28;10(1):12687.

6. Rémy B, Mion S, Plener L, Elias M, Chabrière E, Daudé D. Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective. Front Pharmacol. 2018 Mar 7;9:203.

7. Anonye BO, Nweke V, Furner-Pardoe J, Gabrilska R, Rafiq A, Ukachukwu F, Bruce J, Lee C, Unnikrishnan M, Rumbaugh KP, Snyder LAS, Harrison F. The safety profile of Bald’s eyesalve for the treatment of bacterial infections. Sci Rep. 2020 Oct 15;10(1):17513.

1. “Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens”

International Journal of Cardiology, 2013

2. ”The Effect of Coenzyme Q10 on Morbidity and Mortality in Chronic Heart Failure: Results From Q-SYMBIO: A Randomized Double-Blind Trial”

JACC, Heart Failure, 2014

 3. “Selenium and Coenzyme Q10 Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality—Sub-Study of a Randomized Clinical Trial”

Nutrients, 2022

 4. “Association of dietary selenium intake with telomere length I middle-aged and older adults”

Clinical Nutrition, januari 2020

1. Food as a Catalyst for Change, en föreläsning arrangerad av The Peace Research Institute Oslo (PRIO), 5 Sep 2022. https://www.prio.org/events/8964

 2. Kormann C. How Owamni Became the Best New Restaurant in the United States. The New Yorker, 2022-11-12. https://www.newyorker.com/magazine/2022/09/19/how-owamni-became-the-best-new-restaurant-in-the-united-states

 3. U.S. Department of Health & Human Services. Diabetes and American Indians/Alaska Natives

https://minorityhealth.hhs.gov/diabetes-and-american-indiansalaska-natives  Hämtad 2024-02-13.

 4. U.S. Department of Health & Human Services. Heart Disease and American Indians/Alaska Natives.

https://minorityhealth.hhs.gov/heart-disease-and-american-indiansalaska-natives   Hämtad 2024-02-13.

1. Kumar P, Liu C, Suliburk J, Hsu JW, Muthupillai R, Jahoor F, Minard CG, Taffet GE, Sekhar RV. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78 (1):75-89.

​​2. Nguyen D, Samson SL, Reddy VT, Gonzalez EV, Sekhar RV. Impaired mitochondrial fatty acid oxidation and insulin resistance in aging: novel protective role of glutathione. Aging Cell. 2013 Jun;12(3):415-25.

3. Meléndez-Hevia E, De Paz-Lugo P, Cornish-Bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009 Dec;34(6):853-72.

4. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701.

5. Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015 May;40(6):1405-16.

6. Alves A, Bassot A, Bulteau AL, Pirola L, Morio B. Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. 2019 Jun 16;11(6):1356.

7. Oliver G, Dean O, Camfield D, Blair-West S, Ng C, Berk M, Sarris J. N-acetyl cysteine in the treatment of obsessive compulsive and related disorders: a systematic review. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):12-24.

8. Liu YJ, Janssens GE, McIntyre RL, Molenaars M, Kamble R, Gao AW, Jongejan A, Weeghel MV, MacInnes AW, Houtkooper RH. Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion. PLoS Genet. 2019 Mar 7;15(3):e1007633.

9. Oh SI, Park JK, Park SK. Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans. Clinics (Sao Paulo). 2015 May;70(5):380-6.

10. Kumar P, Osahon OW, Sekhar RV. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients. 2022 Mar 7;14(5):1114.

11. Lizzo G, Migliavacca E, Lamers D, Frézal A, Corthesy J, Vinyes-Parès G, Bosco N, Karagounis LG, Hövelmann U, Heise T, von Eynatten M, Gut P. A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage. Front Aging. 2022 Mar 7;3:852569.

12. Baylor College of Medicine. GlyNAC supplementation reverses aging hallmarks in aging humans. Pressmeddelande 2022-08-17. https://www.bcm.edu/news/glynac-supplementation-reverses-aging-hallmarks-in-aging-humans

1. SCB, Utan barn – skillnader i barnlöshet mellan kvinnor och män i olika grupper Demografiska rapporter 2020:1 Utan barn (scb.se)

2. Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations – PubMed (nih.gov)

3. Babayev E, Seli E. Oocyte mitochondrial function and reproduction. Curr Opin Obstet Gynecol. 2015 Jun;27(3):175-81. Oocyte mitochondrial function and reproduction – PMC (nih.gov)

4. Pizzorno J. Mitochondria-Fundamental to Life and Health. Integr Med (Encinitas). 2014 Apr;13(2):8-15. Mitochondria—Fundamental to Life and Health – PMC (nih.gov)

5. May-Panloup P et al. Embryo and Its Mitochondria. Antioxidants (Basel). 2021 Jan 20;10(2):139. Embryo and Its Mitochondria – PMC (nih.gov)

6. Ben-Meir A et al. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell. 2015 Oct;14(5):887-95. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging – PubMed (nih.gov)

7. Bonomi M et al. Blood cell mitochondrial DNA content and premature ovarian aging. PLoS One. 2012;7(8):e42423. Blood Cell Mitochondrial DNA Content and Premature Ovarian Aging – PMC (nih.gov)

8. Thakur AS et al. Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients. Indian J Clin Biochem. 2016 Jul;31(3):342-8. Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients – PMC (nih.gov)

9. Xu Y et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018 Mar 27;16(1):29. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial – PMC (nih.gov)

10. Ozdemir A et al. (2019) Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing in Vitro Fertilization for Unexplained Infertility. Open Journal of Obstetrics and Gynecology, 9, 1-9. Antioxidant Supplement Improves the Pregnancy Rate in Patients Undergoing in Vitro Fertilization for Unexplained Infertility (scirp.org)

11. Hosoe K et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers – PubMed (nih.gov)

12. Ikematsu H et al. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol. 2006 Apr;44(3):212-8. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial – PubMed (nih.gov)

13. Zhang Y et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct. 2018 Nov 14;9(11):5653-5659. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men – PubMed (nih.gov)

14. García-Corzo L et al. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency. Biochim Biophys Acta. 2014 Jul;1842(7):893-901. Ubiquinol-10 ameliorates mitochondrial encephalopathy associated with CoQ deficiency – PubMed (nih.gov)

1.Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013 Sep 1;167(5):1860-6.

2. Mortensen SA, Rosenfeldt F, Kumar A, Dolliner P, Filipiak KJ, Pella D, Alehagen U, Steurer G, Littarru GP; Q-SYMBIO Study Investigators. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC Heart Fail. 2014 Dec;2(6):641-9.

3. Opstad TB, Alexander J, Aaseth JO, Larsson A, Seljeflot I, Alehagen U. Selenium and Coenzyme Q10Intervention Prevents Telomere Attrition, with Association to Reduced Cardiovascular Mortality-Sub-Study of a Randomized Clinical Trial. Nutrients. 2022 Aug 15;14(16):3346.

4. Shu Y, Wu M, Yang S, Wang Y, Li H. Association of dietary selenium intake with telomere length in middle-aged and older adults. Clin Nutr. 2020 Oct;39(10):3086-3091.

1. Effect of levothyroxine sodium combined

with selenium supplement.International Journal of Clinical and Experimental Medicine, 2020;13(7):4695-4703

2. Derumeaux H, Valeix P, Castetbon K, Bensimon M, Boutron-Ruault MC, Arnaud J, Hercberg S. Association of selenium with thyroid volume and echostructure in 35- to 60-year-old French adults. Eur J Endocrinol. 2003 Mar;148(3):309-15. 3 Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013 Sep 1;167(5):1860-6.  4 Outzen M, Tjønneland A, Larsen EH, Andersen KK, Christensen J, Overvad K, Olsen A. The effect on selenium concentrations of a randomized intervention with fish and mussels in a population with relatively low habitual dietary selenium intake. Nutrients. 2015 Jan 15;7(1):608-24.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664913/