Nr 6, 2020: Cancer

Så mäter du din kondition

  1. Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT. The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study.Eur Heart J. 2004; 25:1428–1437.

  2. Blair SN, Kohl HW, Paffenbarger RS, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality: a prospective study of healthy men and women.JAMA. 1989; 262:2395–2401.

  3. Sui X, LaMonte MJ, Blair SN. Cardiorespiratory fitness as a predictor of nonfatal cardiovascular events in asymptomatic women and men.Am J Epidemiol. 2007; 165:1413–1423.

  4. Sawada SS, Lee IM, Naito H, Kakigi R, Goto S, Kanazawa M, Okamoto T, Tsukamoto K, Muto T, Tanaka H, Blair SN. Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men.BMC Public Health. 2014; 14:1012.

Hur går det till när C-vitamin dödar cancerceller?

[1] Lim JY, Kim D, Kim BR, Jun JS, Yeom JS, Park JS, Seo JH, Park CH, Woo HO, Youn HS, Baik SC, Lee WK, Cho MJ, Rhee KH. Vitamin C induces apoptosis in AGS cells via production of ROS of mitochondria. Oncol Lett. 2016 Nov;12(5):4270-4276.

[2] Doskey CM, Buranasudja V, Wagner BA, Wilkes JG, Du J, Cullen JJ, Buettner GR. Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy. Redox Biol. 2016 Dec;10:274-284.

[3] Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010 Jul 7;5(7):e11414.

[4] Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3685-9.

[5] Cameron E, Pauling L. Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4538-42.

[6] Chen P, Yu J, Chalmers B, Drisko J, Yang J, Li B, Chen Q. Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy. Anticancer Drugs. 2012 Apr;23(4):437-44.

[7] Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015 Dec 11;350(6266):1391-6.

[8] Padayatty SJ, Riordan HD, Hewitt SM, Katz A, Hoffer LJ, Levine M. Intravenously administered vitamin C as cancer therapy: three cases. CMAJ. 2006 Mar 28;174(7):937-42.

[9] Taxman ET, Conlon ED, Speers A, Dismuke KL, Heyman TS, Taxman TL. Chemotherapy and Functional Medicine in a Patient With Metastatic Breast Cancer: A Case Report. Integr Med (Encinitas). 2016 Mar;15(1):27-32.

[10] Mikirova N, Hunnunghake R, Scimeca RC, Chinshaw C, Ali F, Brannon C, Riordan N. High-Dose Intravenous Vitamin C Treatment of a Child with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Case Report. Am J Case Rep. 2016 Oct 24;17:774-781.

[11] Carr AC, Cook J. Intravenous Vitamin C for Cancer Therapy – Identifying the Current Gaps in Our Knowledge. Front Physiol. 2018 Aug 23;9:1182.

[12] Thompson D. Intravenous Vitamin C May Boost Chemo’s Cancer-Fighting Power. HealthDay, 2014-02-05.

[13] Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9.

[14] Lorenzato A, Magri A, Matafora V. Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer. Cancers (Basel). 2020 Mar 14;12(3):685.

[15] Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, et al. O2⋅- and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. 2017 Apr 10;31(4):487-500.e8.

[16] Magri A, Germano G, Lorenzato A, Lamba S, Chilà R, et al. High-dose vitamin C enhances cancer immunotherapy. Sci Transl Med. 2020 Feb 26;12(532):eaay8707.

[17] Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R et al. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun. 2020 May 11;11(1):2332.

[18] Vårdguiden. ”Vad är G6PD?” https://www.1177.se/Stockholm/fragor–svar/nationellt/sjukdomar–besvar/vad-ar-g6pd/ Hämtad 20-11-18.

Kan antioxidanter öka risken för cancer?

[1] Le Gal K, Ibrahim MX, Wiel C, Sayin VI, Akula MK, Karlsson C, Dalin MG, Akyürek LM, Lindahl P, Nilsson J, Bergo MO. Antioxidants can increase melanoma metastasis in mice. Sci Transl Med. 2015 Oct 7;7(308):308re8.

[2] Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. 2014 Jan 29;6(221):221ra15.

[3] Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. 2014 Jan 29;6(221):221ra15.

Mutationsteorins utmanare: ”Cancer kan inte leva utan glutamin och glukos”

[i] İyikesici MS, Slocum AK, Slocum A, Berkarda FB, Kalamian M, Seyfried TN. Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer. Cureus. 2017 Jul 7;9(7):e1445.

[ii] https://www.facebook.com/pablosbrainjourney/

[iii] Meidenbauer JJ, Mukherjee P, Seyfried TN. The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. Nutr Metab (Lond). 2015 Mar 11;12:12.

[iv] Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, Kondakci G, Narain NR, Kiebish MA, Bronson RT, Arismendi-Morillo G, Chinopoulos C, Seyfried TN. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Commun Biol. 2019 May 29;2:200.

[v] Augur ZM, Doyle CM, Li M, Mukherjee P, Seyfried TN. Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma. Front Nutr. 2018 Oct 5;5:91.

[vi] Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, Kondakci G, Narain NR, Kiebish MA, Bronson RT, Arismendi-Morillo G, Chinopoulos C, Seyfried TN. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Commun Biol. 2019 May 29;2:200.

[vii] https://www.facebook.com/pablosbrainjourney/posts/1955319981383663

[viii] Poff AM, Ari C, Seyfried TN, D’Agostino DP. The ketogenic diet and hyperbaric oxygen therapy prolong survival in mice with systemic metastatic cancer. PLoS One. 2013 Jun 5;8(6):e65522.

[ix] İyikesici MS. Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer. Int J Hyperthermia. 2019;36(1):446-455.

[x] Pawelek JM. Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer. Chin J Cancer. 2014 Mar;33(3):133-9. doi: 10.5732/cjc.013.10243. PMID: 24589183; PMCID: PMC3966146.

[xi] Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi RK, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res. 2012 Jan 15;18(2):370-9.

[xii] Stratton MR, Campbell PJ, Futreal PA. The cancer genome. Nature. 2009 Apr 9;458(7239):719-24.

[xiii] Soto AM, Sonnenschein C. The somatic mutation theory of cancer: growing problems with the paradigm? Bioessays. 2004 Oct;26(10):1097-107.

[xiv] Aguilera O, Muñoz-Sagastibelza M, Torrejón B, Borrero-Palacios A, Del Puerto-Nevado L, Martínez-Useros J, Rodriguez-Remirez M, Zazo S, García E, Fraga M, Rojo F, García-Foncillas J. Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. Oncotarget. 2016 Jul 26;7(30):47954-47965.

Cancer och immunterapi

1. Douglas Hanahan, Robert A. Weinberg. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.

2. Maria V. Liberti, Jason W. Locasale. The Warburg Effect: How Does it Benefit Cancer Cells? Trends Biochem Sci. 2016;41(3):211-218.

3.Dominique C. Hinshaw, Lalita A. Shevde. The Tumor Microenvironment Innately Modulates Cancer Progression.

4. Grens K. Cancer Immunotherapy Trial Suspended After Deaths. The Scientist, 2016-07-08.

5. Söderlund Leifler K.Immunsystemet får hjälp att bekämpa cancer. Forskning & framsteg. 2014-06-08

6. John Hopkins Medicine. Side effects of immunotherapy: what to look for and when? Blogginlägg 2016-06-23.

7. John Hopkins Medicine. New Cancer Immunotherapy Drugs Linked To Arthritis in Some Patients. Pressmeddelande 2016-06-23.

8.https://www.pnas.org/content/early/2020/11/20/2015343117

9. Wang J, Yang HR, Wang DJ, Wang XX. Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors. Oncol Lett. 2020 Dec;20(6):342.

10. Cancerfonden. Kroppens eget försvar väcker hopp om bot. Blogginlägg 2014-05-28.

11. Wang J, Yang HR, Wang DJ, Wang XX. Association between the gut microbiota and patient responses to cancer immune checkpoint inhibitors. Oncol Lett. 2020 Dec;20(6):342.

12. Hawrelak JA, Myers SP. The causes of intestinal dysbiosis: a review. Altern Med Rev. 2004 Jun;9(2):180-97. PMID: 15253677.

13. Bastyr University. Probiotics and the Immune System. Blogginlägg 2010-11-08.

14. Kitamura M.How Gut Bacteria Are Shaking Up Cancer Research. Bloomberg 2016-03-14

15. UChicago News. Gut bacteria can dramatically amplify cancer immunotherapy. Pressmeddelande 2015-11-06.

16. Vétizou M, Pitt JM, Daillère R, et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. 2015 Nov 27;350(6264):1079-84.

17. Ramin Rezaee, Amir Abbas Momtazi, Alireza Monemi, Amirhossein Sahebkar. Curcumin: A potentially powerful tool to reverse cisplatin-induced toxicity. Pharmacol Res. 2017;117:218-227.

18. Dona Sinha, Nivedita Sarkar, Jaydip Biswas, Anupam Bishayee. Resveratrol for breast cancer prevention and therapy: Preclinical evidence and molecular mechanisms. Semin Cancer Biol. 2016;40-41:209-232.

19. Lindsay G. Carter, John A. D’Orazio, Kevin J. Pearson. Resveratrol and cancer: focus on in vivo evidence. Endocr Relat Cancer. 2014;21(3):R209-R225.

Lästips:

  • Cancer: The Journey from Diagnosis to Empowermentav Anderson, Paul.

  • A. Radical Remission: Surviving Cancer Against All Odds, av Turner, Kelly

  • Outside the Box Cancer Therapies: Alternative Therapies That Treat and Prevent Cancer, av Stengler, Mark, Anderson, Paul.

  • The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Nontoxic Bio-Individualized Therapies, av Winters, Nasha, Higgins Kelley, Jess, Turner, Jess,

  • Vital Strategies in Cancer, av Roach, Jim.

Tränar du? Du kan ändå röra dig farligt lite

  • Folkhälsomyndigheten

  • Saint-Maurice PF, Troiano RP, Bassett DR Jr, Graubard BI, Carlson SA, Shiroma EJ, Fulton JE, Matthews CE. Association of Daily Step Count and Step Intensity With Mortality Among US Adults.JAMA. 2020 Mar 24;323(12):1151-1160.

  • Physiology of Sport and Exercise Sixth Edition W. Larry Kenney et al

  • Rundqvist H, Veliça P, Barbieri L, Gameiro PA, Bargiela D, Gojkovic M, Mijwel S, Reitzner SM, Wulliman D, Ahlstedt E, Ule J, Östman A, Johnson RS. Cytotoxic T-cells mediate exercise-induced reductions in tumor growth. Elife. 2020 Oct 23;9:e59996.

Metabol ohälsa kan förvärra covid-19

  • de Menezes, Ehrika Vanessa Almeida, et al. ”Influence of Paleolithic diet on anthropometric markers in chronic diseases: systematic review and meta-analysis.” Nutrition journal 18.1 (2019): 41.

  • Yancy, William S., et al. ”A low-carbohydrate, ketogenic diet to treat type 2 diabetes.” Nutrition & metabolism 2.1 (2005): 34.

  • Masharani, Umesh, et al. ”Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes.” European journal of clinical nutrition 69.8 (2015): 944-948.

  • Jönsson, Tommy, et al. ”Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study.” Cardiovascular diabetology 8.1 (2009): 35.

  • Fontes-Villalba, Maelán, et al. ”Palaeolithic diet decreases fasting plasma leptin concentrations more than a diabetes diet in patients with type 2 diabetes: a randomised cross-over trial.” Cardiovascular Diabetology 15.1 (2016): 80.

  • Frassetto, Lynda A., et al. ”Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic–Hunter–Gatherer-type diets.” European journal of clinical nutrition 67.9 (2013): 899-903.

  • Jönsson, Tommy, et al. ”Subjective satiety and other experiences of a Paleolithic diet compared to a diabetes diet in patients with type 2 diabetes.” Nutrition journal 12.1 (2013): 105.

  • Al-Saady, N. M., C. M. Blackmore, and E. D. Bennett. ”High fat, low carbohydrate, enteral feeding lowers PaCO 2 and reduces the period of ventilation in artificially ventilated patients.” Intensive care medicine 15.5 (1989): 290-295.

  • Lakka, Timo A., and David E. Laaksonen. ”Physical activity in prevention and treatment of the metabolic syndrome.” Applied physiology, nutrition, and metabolism 32.1 (2007): 76-88.

Kallbad som medicin

  1. Huttunen, Pirkko, Leena Kokko, and Virpi Ylijukuri. ”Winter swimming improves general well-being.” International Journal of Circumpolar Health 63.2 (2004): 140-144.

  2. Hirvonen, Jorma, et al. ”Plasma catecholamines, serotonin and their metabolites and beta-endorphin of winter swimmers during one winter. Possible correlations to psychological traits.” International journal of circumpolar health 61.4 (2002): 363-372.

  3. Lindeman, Sari, Jorma Hirvonen, and Matti Joukamaa. ”Neurotic psychopathology and alexithymia among winter swimmers and controls-a prospective study.” International journal of circumpolar health 61.2 (2002): 123-130.

  4. Peake, Jonathan M., et al. ”The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise.” The Journal of physiology 595.3 (2017): 695-711.

  5. Siems, W. G., et al. ”Improved antioxidative protection in winter swimmers.” Qjm 92.4 (1999):

  6. Mooventhan, A., and L. Nivethitha. ”Scientific evidence-based effects of hydrotherapy on various systems of the body.” North American journal of medical sciences 6.5 (2014): 199.